Aminobutanol (500 mg)
(±)-2-Amino-1-butanol
CAS: 96-20-8
Molecular Formula: C4H11NO
Aminobutanol (500 mg) - Names and Identifiers
Aminobutanol (500 mg) - Physico-chemical Properties
| Molecular Formula | C4H11NO |
| Molar Mass | 89.14 |
| Density | 0.943 g/mL at 25 °C (lit.) |
| Melting Point | -2 °C (lit.) |
| Boling Point | 176-178 °C (lit.) |
| Flash Point | 184°F |
| Water Solubility | Completely miscible in water |
| Vapor Presure | 58.1Pa at 25℃ |
| Appearance | Liquid |
| Color | Clear |
| Merck | 14,427 |
| BRN | 1098274 |
| pKa | 12.88±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Sensitive | Air Sensitive & Hygroscopic |
| Refractive Index | n20/D 1.452 |
| Physical and Chemical Properties | Colorless liquid. Melting point -2 ℃, boiling point 178 ℃, relative density 0.9162(20/4 ℃), refractive index 1.4489(25 ℃), flash point 84 ℃. Can be mixed with water arbitrarily, soluble in alcohol and ether. It smells of ammonia. The pH of 0.1mol/L solution is 11.1. |
Aminobutanol (500 mg) - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R50 - Very Toxic to aquatic organisms R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2735 8/PG 3 |
| WGK Germany | 2 |
| RTECS | EK9625000 |
| TSCA | Yes |
| HS Code | 29221990 |
| Hazard Class | 8 |
| Packing Group | III |
Aminobutanol (500 mg) - Reference Information
| LogP | -0.45 at 20℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | for the preparation of emulsifiers, surfactants and vulcanization accelerators, organic synthesis, acid gas absorbers. 2-amino butanol was obtained by resolution, which was used for the production of anti-tuberculosis drug ethambutol. |
| production method | the reaction of butene-1 with acetonitrile and chlorine gas is chlorination, followed by hydrolysis, alcoholization, obtained by alkalization. In addition to the alkalization operation, the process is carried out continuously in the piped plant in the following order. The purity of butene-1 is 50-80%. The molar ratio of the chlorination reaction is butene-1: Chlorine: acetonitrile = 1:0.85:7-8. The reaction temperature is 40-50 ° C., and the feed flow rate is 2.5-3.0/h. After completion of the chlorination reaction, acetonitrile and dichlorobutane in the reaction were recovered by distillation using an acetonitrile recovery column. Then, the alcoholysis reaction is carried out, and the distillate reaction liquid is added to hydrochloric acid and ethanol equivalent to the weight of butene-1, and fed at atmospheric pressure. The temperature at the bottom of the column is 104 ° C. And the temperature at the top of the column is 72-75 ° C, A mixture of ethyl acetate, water, and ethanol, which was prepared by evaporation while reacting. Alcoholysis reaction solution, and then sodium hydroxide alkalization, distillation to obtain crude 2-amino butanol. Finally, the content of more than 95% of the product was fractionated under reduced pressure. |
| category | combustible liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-mouse LD50: 2300 mg/kg; Intraperitoneal-mouse LDL0:250 mg/kg |
| flammability hazard characteristics | near-fire, when exposed to heat, when exposed to oxidant, flammable; toxic NOx smoke from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| Occupational Standard | 165 F |
Last Update：2024-04-09 20:52:54
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